Labetalol Hydrochloride (Normodyne, Trandate)

Heart rate - Labetalol administration does NOT drastically reduce heart rate or result in reflex tachycardia. Blood pressure - Labetalol will produce a dose-dependent decrease in blood pressure. Cerebral blood flow and ICP should remain unaffected. Bronchoconstriction - Labetalol blocks B2 adrenergic receptors, which could contribute to bronchospasm in susceptible patients. As a beta blocker, labetalol will increase resistance to beta agonists (eg albuterol), so be careful with the respiratory patients! Drug interactions - Labetalol will supress/blunt reflex tachycardia seen with administration of nitroglycerin. Hypotensive affects of volatile anesthetics, opoids, etc will be potentiated by labetalol. Cimetidine will increase labetalol bioavailability. OB - Neonatal hypoglycemia and bradycardia risk is increased when the mother is given labetalol at the time of delivery

Bronchial Asthma Overt cardiac failure 2nd and 3rd degree heart blocks Cardiogenic shock Severe bradycardia

2.5 - 20 mg. Slow push over 2 minutes

0.5 - 2.0 mg/min. MAX: cumulative dose of 1-4 mg/kg Typically prepared by adding 200 mg of labetalol in 200 ml of normal saline or D5W for a concentration of 1 mg/ml

Labetalol is a selective, competitive, and alpha 1-adrenergic antagonist. In addition, labetalol is a non-selective, competitive, beta-adrenergic (B1 and B2) blocker. The ratio is 1:7 alpha to beta blockade.

Hepatic, urinary, fecal