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Gastroesophageal Reflux Disease (GERD)

Anesthesia Implications

Updated On: July 23, 2026

Anesthesia Implications

Aspiration risk - GERD raises the risk of regurgitation and aspiration; weigh it in airway planning, especially alongside other risk factors.

Rapid-sequence induction - For significant reflux or risk, consider an RSI with cricoid pressure and a secured airway rather than prolonged mask ventilation.

Aspiration prophylaxis - Consider a nonparticulate antacid, an H2 blocker, or a prokinetic where indicated, and continue the patient's acid suppression.

Airway at emergence - Aspiration risk persists at emergence — extubate awake with intact reflexes.

Positioning - Head-up positioning can reduce reflux during induction.

Pathophysiology

Gastroesophageal reflux disease is retrograde flow of gastric contents into the esophagus from an incompetent lower esophageal sphincter.

For the anesthetist its importance is singular and practical: it marks a patient at increased risk of regurgitation and pulmonary aspiration of gastric contents during induction and emergence, when airway reflexes are obtunded. Severe or symptomatic reflux, along with other risk factors (hiatal hernia, obesity, pregnancy, delayed emptying), shifts airway management toward aspiration precautions.


Suggested Reading

Hemmings HC Jr, Yao FF, Goldstein PA, et al, eds. Yao & Artusio's Anesthesiology: Problem-Oriented Patient Management. 10th ed. Wolters Kluwer; 2025.
Gropper MA, Eriksson LI, Fleisher LA, et al, eds. Miller's Anesthesia. 10th ed. Elsevier; 2024.
Hines RL, ed. Stoelting's Anesthesia and Co-Existing Disease. 8th ed. Elsevier; 2021.
Horstmann R, Classen C, Röttgermann S, et al. Long-term experience of treating 185 patients with gastroesophageal reflux disease (GERD) by anti-reflux surgery respecting the functional-morphological restoration of the esophagus. Langenbecks Arch Surg. 2006. PMID: 16328397.
van der Peet DL, Klinkenberg-Knol EC, Eijsbouts QA, et al. Laparoscopic Nissen fundoplication for the treatment of gastroesophageal reflux disease (GERD). Surgery after extensive conservative treatment. Surg Endosc. 1998. PMID: 9716773.