Anesthesia Implications

Use PO in pre-op for acute pain following surgery in patients who need a multimodal pain plan. Good for cases that are longer as the peak onset is 24 hours after administration. A one time 400mg administration of celecoxib was shown to decrease need for larger dosages of oral analgesic medication post-operatively.

Classification: Cox-2 Inhibitor (NSAID)

Time to Onset: 24 hours

Time to Peak: Unknown

Duration: 12-24hours

Method of Action: Cox-2 enzyme inhibitor: anti-inflammatory, analgesic, and antipyretic properties

Metabolism: Hepatic – CYP2C9

Elimination: Renal

Additional Notes:
Avoid in people with hepatic disease, NSAID sensitivity, or pregnant individuals. Caution in cardiac patients as there is an increased risk for thrombotic events.